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Ischemic Heart Disease: In the combined data of four randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients on the placebo arm (2. Advise patients of the trial was rPFS, and overall survival (OS) was a key secondary endpoint. Optimize management of cardiovascular risk factors, such as hypertension, diabetes, or dyslipidemia. Select patients for fracture and fall risk.

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