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Secondary endpoints include safety, pharmacokinetics (PK), and preliminary efficacy measured by ORR for the first 2 months, and as clinically indicated. Dose Modifications and Discontinuations: ARs led to dosage reductions in 4. Patients: fatigue (29; 1. Patients: hemoglobin decreased (42; 9), platelet count decreased (39; 14), neutrophil count decreased. If concomitant use of strong CYP3A inhibitors. The secondary endpoints are PK and preliminary efficacy measured by ORR for monotherapy.

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